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KMID : 0363320010220040639
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Journal of Korean Oriental Internal Medicine
2001 Volume.22 No. 4 p.639 ~ p.645
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Study on the Anti-angiogenic Therapy to Cancer disease with Oriental medicine
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Choi Woo-Jin
Song Kee-Cheol
Choi Byung-Ryel
Lee Yong-Yeon
Seo Sang-Hoon
Yoo Hwa-Seung
Cho Jung-Hyo
Lee Yeon-Weol
Son Chang-Gyu
Cho Chong-Kwan
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Abstract
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Angiogenesis is a fundamental process in reproduction and wound healing. Under these condition, neovascularization is tightly regulated. Unregulated angiogenesis may lead to several angiogenic diseases, and is thought to be indispensible for solid tumor growth and metastsis. The construction of new vascular network is a multistep cascade involving basement membrane degradation, endothelial cell proliferation, endothelial cell migration, and tube formation. Newly reported anti-angiogenic agents in oriental medical field have targeted both specific and multistep stages in the angiogenic process. From recent approach in oriental medical field with several herb medicines including activating blood flow and removing blood stasis medicine(活血化瘀藥), it may be possible in the future to develope specific anti-angiogenic agents that offer a less toxic potential therapy for cancer and angiogenic disease.
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KEYWORD
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Angiogenesis, tumor growth, metastsis, endothelial cell
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